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A Structural Perspective on Respiratory Complex I
192,59 € *
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Complex I (NADH:ubiquinone oxidoreductase) is the first and largest enzyme of the respiratory chain in mitochondria and plays a central role in cellular energy production. Complex I dysfunction has been implicated in many human neurodegenerative diseases, including Parkinson s. Mutations in complex I subunits are among the most common human genetic disorders known. Until recently, in the absence of structural information, complex I was the least understood enzyme of the respiratory chain. The mechanism by which it couples electron transfer between NADH and quinone to the translocation of protons across the membrane was a complete enigma.Recent years have been marked by spectacular progress in the elucidation of complex I s structure, finally allowing the interpretation of a wealth of data accumulated in about 50 years since the discovery of the enzyme. Understanding of the mechanism of this large molecular machine, involving long-range conformational changes, is beginning to emerge. This book is the first devoted entirely to complex I. It contains chapters written by leaders in the field, covering a wide range of topics from the structure of the complex, properties of its many redox centers, subunit composition, mutagenesis studies, evolution of the enzyme and on to the current understanding of the coupling mechanism and the molecular basis for human pathologies. Features:- Concise and authoritative review of current state-of-the-art in research on respiratory complex I- The first book entirely devoted to complex I, a central enzyme in bioenergetics- Recent breakthroughs in structure elucidation finally allow understanding of the mechanism- Mutations leading to common and severe human disorders are discussed. The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

Anbieter: Dodax
Stand: 04.04.2020
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Your luck is just around the corner! Happy food...
51,90 CHF *
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Do you have health problems or mood swings? Do you have weight problems or just feel unhappy most of the time? In Your luck is just around the corner - happy food- happy mood you will find some answers nobody will tell you from the beginning. There is a huge industry behind food, especially processed food and it is making us sick. Instead of living a longer healthier life diseases like diabetes, stroke, cardio vascular problems, Alzheimer disease, Parkinson, allergies and cancer appear everywhere around us. The answer why and a possible way to overcome these issues are written in this book. Feel free to take from this book whatever you like and enjoy a new healthy high vibrant feeling in your body, happy feelings and a glowing skin as well.

Anbieter: Orell Fuessli CH
Stand: 04.04.2020
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Synaptic Plasticity and the Mechanism of Alzhei...
228,00 CHF *
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During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously 'idiopathic' brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. As progress in deciphering genotype-to-phenotype relationships in AD accelerated during the last two decades, it became apparent that the key challenge for understanding and ultimately treating AD was to focus not on what was killing neurons over the course of the disease but rather on what was interfering subtly and intermittently with episodic declarative memory well before widespread neurodegeneration had occurred . In other words, one wishes to understand the factors underlying early synaptic dysfunction in the hippocampus and then attempt to neutralize these as soon as feasible, perhaps even before a definitive diagnosis of AD can be made. This steady movement of the field toward ever-earlier stages of the disorder is exemplified by the recognition and intensive study of minimal cognitive impairment–amnestic type (MCI; . And yet patients who die with a diagnosis of MCI have been found to already have a histopathology essentially indistinguishable from classical AD . Therefore, even earlier phases of this continuum are likely to become recognized, and these might show milder histopathology and might have biochemically, but not yet microscopically, detectable Ab species that mediate synaptic dysfunction. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.

Anbieter: Orell Fuessli CH
Stand: 04.04.2020
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Muscle Aging, Inclusion-Body Myositis and Myopa...
198,00 CHF *
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Muscle weakness with ageing is almost inevitable, generally beginning to manifest beyond the age of 40, and is usually unstoppable. It can lead to reduced mobility, increased risk of falling, injury, and even death. But 'you're just getting old' is not a sufficient diagnosis. Specific causes of neuromuscular symptoms may explain progressive muscle weakness, and should be investigated for potential treatment. Muscle Ageing, Inclusion-Body Myositis and Myopathies explores the clinical and pathological expression of muscle weakness in aging persons. Case studies demonstrate how physicians can more accurately diagnose weakening elderly patients and make better management decisions. It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies. The former, the most common progressive muscle disease in the over 50s, is frequently under-diagnosed and, with the increasing population of aged individuals, is presenting a greater challenge. This disease of muscle has pathological similarities with the well-known Alzheimer and Parkinson brain diseases. Edited and written by a leading international cast of authors, Muscle Ageing, Inclusion-Body Myositis and Myopathies provides a state-of-the-art guide to ageing-associated neuromuscular disorders. It should be in the hands of all those involved in the care of aging and muscle-weakened patients. Titles of Related Interest Neuromuscular Disorders Tawil and Vennance (eds); ISBN 978-0-470-65456-9 European Handbook of Neurological Management, Vol 1, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2 European Handbook of Neurological Management, Vol 2, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9

Anbieter: Orell Fuessli CH
Stand: 04.04.2020
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Neurodegeneration
140,00 CHF *
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This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson s Disease, Alzheimer s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

Anbieter: Orell Fuessli CH
Stand: 04.04.2020
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Muscle Aging, Inclusion-Body Myositis and Myopa...
115,00 CHF *
ggf. zzgl. Versand

Muscle weakness with ageing is almost inevitable, generally beginning to manifest beyond the age of 40, and is usually unstoppable. It can lead to reduced mobility, increased risk of falling, injury, and even death. But you re just getting old is not a sufficient diagnosis. Specific causes of neuromuscular symptoms may explain progressive muscle weakness, and should be investigated for potential treatment. Muscle Ageing, Inclusion-Body Myositis and Myopathies explores the clinical and pathological expression of muscle weakness in aging persons. Case studies demonstrate how physicians can more accurately diagnose weakening elderly patients and make better management decisions. It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies. The former, the most common progressive muscle disease in the over 50s, is frequently under-diagnosed and, with the increasing population of aged individuals, is presenting a greater challenge. This disease of muscle has pathological similarities with the well-known Alzheimer and Parkinson brain diseases. Edited and written by a leading international cast of authors, Muscle Ageing, Inclusion-Body Myositis and Myopathies provides a state-of-the-art guide to ageing-associated neuromuscular disorders. It should be in the hands of all those involved in the care of aging and muscle-weakened patients. Titles of Related Interest Neuromuscular Disorders Tawil and Vennance (eds); ISBN 978-0-470-65456-9 European Handbook of Neurological Management, Vol 1, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2 European Handbook of Neurological Management, Vol 2, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9

Anbieter: Orell Fuessli CH
Stand: 04.04.2020
Zum Angebot
Your luck is just around the corner! Happy food...
4,40 CHF *
ggf. zzgl. Versand

Do you have health problems or mood swings? Do you have weight problems or just feel unhappy most of the time? In Your luck is just around the corner - happy food- happy mood you will find some answers nobody will tell you from the beginning. There is a huge industry behind food, especially processed food and it is making us sick. Instead of living a longer healthier life diseases like diabetes, stroke, cardio vascular problems, Alzheimer disease, Parkinson, allergies and cancer appear everywhere around us. The answer why and a possible way to overcome these issues are written in this book. Feel free to take from this book whatever you like and enjoy a new healthy high vibrant feeling in your body, happy feelings and a glowing skin as well.

Anbieter: Orell Fuessli CH
Stand: 04.04.2020
Zum Angebot
Your luck is just around the corner! Happy food...
30,90 € *
ggf. zzgl. Versand

Do you have health problems or mood swings? Do you have weight problems or just feel unhappy most of the time? In Your luck is just around the corner - happy food- happy mood you will find some answers nobody will tell you from the beginning. There is a huge industry behind food, especially processed food and it is making us sick. Instead of living a longer healthier life diseases like diabetes, stroke, cardio vascular problems, Alzheimer disease, Parkinson, allergies and cancer appear everywhere around us. The answer why and a possible way to overcome these issues are written in this book. Feel free to take from this book whatever you like and enjoy a new healthy high vibrant feeling in your body, happy feelings and a glowing skin as well.

Anbieter: Thalia AT
Stand: 04.04.2020
Zum Angebot
Muscle Aging, Inclusion-Body Myositis and Myopa...
146,99 € *
ggf. zzgl. Versand

Muscle weakness with ageing is almost inevitable, generally beginning to manifest beyond the age of 40, and is usually unstoppable. It can lead to reduced mobility, increased risk of falling, injury, and even death. But 'you're just getting old' is not a sufficient diagnosis. Specific causes of neuromuscular symptoms may explain progressive muscle weakness, and should be investigated for potential treatment. Muscle Ageing, Inclusion-Body Myositis and Myopathies explores the clinical and pathological expression of muscle weakness in aging persons. Case studies demonstrate how physicians can more accurately diagnose weakening elderly patients and make better management decisions. It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies. The former, the most common progressive muscle disease in the over 50s, is frequently under-diagnosed and, with the increasing population of aged individuals, is presenting a greater challenge. This disease of muscle has pathological similarities with the well-known Alzheimer and Parkinson brain diseases. Edited and written by a leading international cast of authors, Muscle Ageing, Inclusion-Body Myositis and Myopathies provides a state-of-the-art guide to ageing-associated neuromuscular disorders. It should be in the hands of all those involved in the care of aging and muscle-weakened patients. Titles of Related Interest Neuromuscular Disorders Tawil and Vennance (eds); ISBN 978-0-470-65456-9 European Handbook of Neurological Management, Vol 1, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2 European Handbook of Neurological Management, Vol 2, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9

Anbieter: Thalia AT
Stand: 04.04.2020
Zum Angebot